Nature Communications (Dec 2016)

Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism

  • Kun-Mou Li,
  • Craig Wilkinson,
  • Juho Kellosalo,
  • Jia-Yin Tsai,
  • Tommi Kajander,
  • Lars J. C. Jeuken,
  • Yuh-Ju Sun,
  • Adrian Goldman

DOI
https://doi.org/10.1038/ncomms13596
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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In some parasites, membrane-bound pyrophosphatases, which couple proton and sodium ion transport across the membrane, are important for infectivity. Here, the authors report crystal structures of these proteins alongside biophysical analyses that allow them to propose a model for how the coupling is achieved.