Nature Communications (Oct 2022)

Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context

  • Elisa Setten,
  • Alessandra Castagna,
  • Josué Manik Nava-Sedeño,
  • Jonathan Weber,
  • Roberta Carriero,
  • Andreas Reppas,
  • Valery Volk,
  • Jessica Schmitz,
  • Wilfried Gwinner,
  • Haralampos Hatzikirou,
  • Friedrich Feuerhake,
  • Massimo Locati

DOI
https://doi.org/10.1038/s41467-022-34241-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 22

Abstract

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Renal fibrosis is a progressive process with complex etiopathology, causing organ failure. Here authors present a mathematical model, based on an in vitro system faithfully contemplating macrophage-fibroblast interaction and the metabolic-immunologic signals that are affecting kidney fibrosis, that is applicable to kidney transplant failure.