Nature Communications (Oct 2016)
Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10
- Lars Ellenrieder,
- Łukasz Opaliński,
- Lars Becker,
- Vivien Krüger,
- Oliver Mirus,
- Sebastian P. Straub,
- Katharina Ebell,
- Nadine Flinner,
- Sebastian B. Stiller,
- Bernard Guiard,
- Chris Meisinger,
- Nils Wiedemann,
- Enrico Schleiff,
- Richard Wagner,
- Nikolaus Pfanner,
- Thomas Becker
Affiliations
- Lars Ellenrieder
- Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg
- Łukasz Opaliński
- Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg
- Lars Becker
- Division of Biophysics, School of Biology/Chemistry, University of Osnabrück
- Vivien Krüger
- Division of Biophysics, School of Biology/Chemistry, University of Osnabrück
- Oliver Mirus
- Molecular Cell Biology of Plants, University of Frankfurt
- Sebastian P. Straub
- Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg
- Katharina Ebell
- Division of Biophysics, School of Biology/Chemistry, University of Osnabrück
- Nadine Flinner
- Molecular Cell Biology of Plants, University of Frankfurt
- Sebastian B. Stiller
- Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg
- Bernard Guiard
- Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique
- Chris Meisinger
- Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg
- Nils Wiedemann
- Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg
- Enrico Schleiff
- Molecular Cell Biology of Plants, University of Frankfurt
- Richard Wagner
- Division of Biophysics, School of Biology/Chemistry, University of Osnabrück
- Nikolaus Pfanner
- Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg
- Thomas Becker
- Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg
- DOI
- https://doi.org/10.1038/ncomms13021
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
The protein Mdm10 is known to be present in the endoplasmic reticulum-mitochondria encounter structure (ERMES) and in mitochondrial sorting and assembly machinery (SAM). Here, the authors examine how this protein interacts with SAM and EMRES, showing that the SAM-mediated protein machinery is independent of ERMES.
