Nature Communications (Apr 2022)
Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association
- Lin Zhu,
- Ting Gao,
- Yi Huang,
- Jing Jin,
- Di Wang,
- Leike Zhang,
- Yanwen Jin,
- Ping Li,
- Yong Hu,
- Yan Wu,
- Hainan Liu,
- Qincai Dong,
- Guangfei Wang,
- Tong Zheng,
- Caiwei Song,
- Yu Bai,
- Xun Zhang,
- Yaoning Liu,
- Weihong Yang,
- Ke Xu,
- Gang Zou,
- Lei Zhao,
- Ruiyuan Cao,
- Wu Zhong,
- Xianzhu Xia,
- Gengfu Xiao,
- Xuan Liu,
- Cheng Cao
Affiliations
- Lin Zhu
- Beijing Institute of Biotechnology
- Ting Gao
- Beijing Institute of Biotechnology
- Yi Huang
- National Biosafety Laboratory, Chinese Academy of Sciences
- Jing Jin
- Institute of Physical Science and Information Technology, Anhui University
- Di Wang
- Institute of Physical Science and Information Technology, Anhui University
- Leike Zhang
- National Biosafety Laboratory, Chinese Academy of Sciences
- Yanwen Jin
- Beijing Institute of Biotechnology
- Ping Li
- Beijing Institute of Biotechnology
- Yong Hu
- Beijing Institute of Biotechnology
- Yan Wu
- National Biosafety Laboratory, Chinese Academy of Sciences
- Hainan Liu
- Beijing Institute of Biotechnology
- Qincai Dong
- Beijing Institute of Biotechnology
- Guangfei Wang
- Beijing Institute of Biotechnology
- Tong Zheng
- Beijing Institute of Biotechnology
- Caiwei Song
- Beijing Institute of Biotechnology
- Yu Bai
- Institute of Physical Science and Information Technology, Anhui University
- Xun Zhang
- Institute of Physical Science and Information Technology, Anhui University
- Yaoning Liu
- Institute of Physical Science and Information Technology, Anhui University
- Weihong Yang
- Institute of Physical Science and Information Technology, Anhui University
- Ke Xu
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Gang Zou
- Insitut Pasteur of Shanghai, Chinese Academy of Sciences
- Lei Zhao
- National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology
- Ruiyuan Cao
- National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology
- Wu Zhong
- National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology
- Xianzhu Xia
- Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences
- Gengfu Xiao
- National Biosafety Laboratory, Chinese Academy of Sciences
- Xuan Liu
- Beijing Institute of Biotechnology
- Cheng Cao
- Beijing Institute of Biotechnology
- DOI
- https://doi.org/10.1038/s41467-022-29948-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Ebola virus virion protein 35 (VP35) is a cofactor of the viral RNA-dependent RNA polymerase, required for viral assembly and IFN antagonist. Here, Zhu et al. provide evidence that EBOV VP35 induces an AKIP1-mediated (human A kinase interacting protein) activation of the PKA-CREB1 signaling pathway and contributes to viral replication and pathogenesis in vitro and in vivo.
