Bezmiâlem Science (Oct 2020)
The Relationship of Hemogram and Inflammatory Biomarkers to Lenght of Stay in Hospital and Clinical Course in Patients with COVID-19
Abstract
Objective:It was aimed to research the relationship between neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), inflammatory markers and lenght of stay in hospital (LOS) with clinical results in hospitalized patients with Coronavirus disease-2019 (COVID-19).Methods:Total leukocyte, neutrophil, lymphocyte and platelet counts (/mm3), hemoglobin (g/dL), mean platelet volume, C-reactive protein (CRP) (mg/L), ferritin (ng/mL), lactate dehydrogenase (LDH) (U/L) creatine kinase (U/L), D-dimer (ng/mL), troponin-I (pg/mL), alanine aminotransferase (U/L), aspartate aminotransferase (U/L) and serum creatinine (mg/dL) measurements were recorded. NLR and PLR were calculated. Applied treatments, intensive care unit requirement, and mortality rates were determined. For LOS and mortality, the sensitivity of biochemical parameters was evaluated.Results:One hundred seventy-one patients (87 females, 84 males) were evaluated. The mean age was 57.9±14.6 years, and the mean LOS was 8.83±6.4 days. There was a positive correlation between NLR and PLR (p<0.05). NLR was correlated with CRP, LDH, ferritin, D-dimer, and troponin-I (p<0.05). LOS was longer in patients with high serum creatinine, CRP, LDH, ferritin, and troponin-I (p<0.05). The need of intensive care unit was observed in 14.6% of the patients and mortality rate was 9.9%. The most used medications were Azithromycin and Hydroxychloroquine. In patients with advanced age, prolonged LOS, and increased inflammation, the frequency of using Favipravir and Tociluzumab was higher.Conclusion:In patients with COVID-19, inflammatory parameters are useful to predict LOS. Increased NLR and PLR seem to be related with poor prognosis.
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