Selective Voltammetric Determination of Paracetamol and Acyclovir on an Electrode Modified with Reduced Graphene Oxide and Gold Particles

Abstract

The electrooxidation of acyclovir (ACv) and paracetamol (PC) on a glassy carbon electrode (GCE) coated with reduced graphene oxide (GOred) and electrodeposited gold particles (Au/GOred/GCE) was studied. The separation of the oxidation peaks of PC and ACv on the Au/GOred/GCE was achieved by decreasing overvoltage. А selective and highly sensitive voltammetric method for the simultaneous determination of PC and ACv was developed. The linear dynamic range of PC and ACv was from 5×10-3 to 5×10-8 M. The proposed method was successfully applied to detect non-metabolized forms of PC and ACv in the presence of human urine.

Keywords

• modified electrodes
• gold particles
• reduced graphene oxide
• acyclovir
• paracetamol
• selective determination