Frontiers in Neurology (Jun 2020)
Diffusion-Weighted Imaging, MR Angiography, and Baseline Data in a Systematic Multicenter Analysis of 3,301 MRI Scans of Ischemic Stroke Patients—Neuroradiological Review Within the MRI-GENIE Study
- Mattias Drake,
- Mattias Drake,
- Petrea Frid,
- Petrea Frid,
- Björn M. Hansen,
- Björn M. Hansen,
- Ona Wu,
- Anne-Katrin Giese,
- Anne-Katrin Giese,
- Markus D. Schirmer,
- Markus D. Schirmer,
- Kathleen Donahue,
- Lisa Cloonan,
- Robert E. Irie,
- Mark J. R. J. Bouts,
- Elissa C. McIntosh,
- Steven J. T. Mocking,
- Adrian V. Dalca,
- Adrian V. Dalca,
- Ramesh Sridharan,
- Huichun Xu,
- Eva Giralt-Steinhauer,
- Lukas Holmegaard,
- Katarina Jood,
- Jaume Roquer,
- John W. Cole,
- Patrick F. McArdle,
- Joseph P. Broderick,
- Jordi Jiménez-Conde,
- Christina Jern,
- Brett M. Kissela,
- Dawn O. Kleindorfer,
- Robin Lemmens,
- Robin Lemmens,
- James F. Meschia,
- Tatjana Rundek,
- Ralph L. Sacco,
- Reinhold Schmidt,
- Pankaj Sharma,
- Pankaj Sharma,
- Agnieszka Slowik,
- Vincent Thijs,
- Vincent Thijs,
- Daniel Woo,
- Bradford B. Worrall,
- Steven J. Kittner,
- Braxton D. Mitchell,
- Braxton D. Mitchell,
- Jonathan Rosand,
- Jonathan Rosand,
- Jonathan Rosand,
- Polina Golland,
- Arne Lindgren,
- Arne Lindgren,
- Natalia S. Rost,
- Johan Wassélius,
- Johan Wassélius
Affiliations
- Mattias Drake
- Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden
- Mattias Drake
- Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden
- Petrea Frid
- Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden
- Petrea Frid
- Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital, Malmö, Sweden
- Björn M. Hansen
- Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden
- Björn M. Hansen
- Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden
- Ona Wu
- Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, United States
- Anne-Katrin Giese
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Anne-Katrin Giese
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States
- Markus D. Schirmer
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Markus D. Schirmer
- Department of Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany
- Kathleen Donahue
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Lisa Cloonan
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Robert E. Irie
- Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, United States
- Mark J. R. J. Bouts
- Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, United States
- Elissa C. McIntosh
- Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, United States
- Steven J. T. Mocking
- Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, United States
- Adrian V. Dalca
- Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, United States
- Adrian V. Dalca
- Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, United States
- Ramesh Sridharan
- Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, United States
- Huichun Xu
- 0Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
- Eva Giralt-Steinhauer
- 1Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), University at Autonoma de Barcelona, Barcelona, Spain
- Lukas Holmegaard
- 2Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
- Katarina Jood
- 2Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
- Jaume Roquer
- 1Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), University at Autonoma de Barcelona, Barcelona, Spain
- John W. Cole
- 3Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, United States
- Patrick F. McArdle
- 0Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
- Joseph P. Broderick
- 4Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States
- Jordi Jiménez-Conde
- 1Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), University at Autonoma de Barcelona, Barcelona, Spain
- Christina Jern
- 5Department of Laboratory Medicine, Institute of Biomedicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
- Brett M. Kissela
- 4Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States
- Dawn O. Kleindorfer
- 4Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States
- Robin Lemmens
- 6Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
- Robin Lemmens
- 7Department of Neurology, VIB, Vesalius Research Center, Laboratory of Neurobiology, University Hospitals Leuven, Leuven, Belgium
- James F. Meschia
- 8Department of Neurology, Mayo Clinic, Jacksonville, FL, United States
- Tatjana Rundek
- 9Department of Neurology and the Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, United States
- Ralph L. Sacco
- 9Department of Neurology and the Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, United States
- Reinhold Schmidt
- 0Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria
- Pankaj Sharma
- 1Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, United Kingdom
- Pankaj Sharma
- 2Ashford and St Peter's Hospital, Surrey, United Kingdom
- Agnieszka Slowik
- 3Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
- Vincent Thijs
- 4Stroke Division, Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia
- Vincent Thijs
- 5Department of Neurology, Austin Health, Heidelberg, VIC, Australia
- Daniel Woo
- 4Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States
- Bradford B. Worrall
- 6Departments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA, United States
- Steven J. Kittner
- 3Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, United States
- Braxton D. Mitchell
- 0Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
- Braxton D. Mitchell
- 7Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, MD, United States
- Jonathan Rosand
- Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, United States
- Jonathan Rosand
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Jonathan Rosand
- 8Henry and Allison McCancer Center for Brain Health and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States
- Polina Golland
- Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, United States
- Arne Lindgren
- 9Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden
- Arne Lindgren
- 0Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital, Lund, Sweden
- Natalia S. Rost
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Johan Wassélius
- Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden
- Johan Wassélius
- Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden
- DOI
- https://doi.org/10.3389/fneur.2020.00577
- Journal volume & issue
-
Vol. 11
Abstract
Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke. Building on baseline MRI examinations from the centralized and structured radiological assessments of ischemic stroke patients in the Stroke Genetics Network, the results of the MRI-Genetics Interface Exploration (MRI-GENIE) study are described in this work.Methods: The MRI-GENIE study included patients with symptoms caused by ischemic stroke (N = 3,301) from 12 international centers. We established and used a structured reporting protocol for all assessments. Two neuroradiologists, using a blinded evaluation protocol, independently reviewed the baseline diffusion-weighted images (DWIs) and magnetic resonance angiography images to determine acute lesion and vascular occlusion characteristics.Results: In this systematic multicenter radiological analysis of clinical MRI from 3,301 acute ischemic stroke patients according to a structured prespecified protocol, we identified that anterior circulation infarcts were most prevalent (67.4%), that infarcts in the middle cerebral artery (MCA) territory were the most common, and that the majority of large artery occlusions 0 to 48 h from ictus were in the MCA territory. Multiple acute lesions in one or several vascular territories were common (11%). Of 2,238 patients with unilateral DWI lesions, 52.6% had left-sided infarct lateralization (P = 0.013 for χ2 test).Conclusions: This large-scale analysis of a multicenter MRI-based cohort of AIS patients presents a unique imaging framework facilitating the relationship between imaging and genetics for advancing the knowledge of genetic traits linked to ischemic stroke.
Keywords
