From CoNFLict to Confidence: Solving a Diagnostic Dilemma Using Neurofilament Light – A Case Report

P.M. Loveland; D. Eratne; S. Holper; N. Yassi; R. Watson

doi:10.33590/emj/10300573

European Medical Journal (Mar 2023)

From CoNFLict to Confidence: Solving a Diagnostic Dilemma Using Neurofilament Light – A Case Report

P.M. Loveland,
D. Eratne,
S. Holper,
N. Yassi,
R. Watson

Affiliations

P.M. Loveland: Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
D. Eratne: Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Neuropsychiatry, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Department of Psychiatry and Melbourne Neuropsychiatry Centre, University of Melbourne, Parkville, Australia; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Australia
S. Holper: Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Department of Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
N. Yassi: Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Department of Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
R. Watson: Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia

DOI: https://doi.org/10.33590/emj/10300573

Abstract

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Distinguishing neurodegenerative from primary psychiatric conditions is often challenging for clinicians, particularly when assessing older people presenting with neuropsychiatric symptoms. Measurement of fluid biomarkers of neurodegeneration is an emerging approach offering improved diagnostic accuracy. This report explores the use of emerging fluid biomarkers to address diagnostic challenges, framed around a case where the diagnosis of delirium with dementia was revised based on biomarker analysis, enabling treatment of a primary mood disorder with disabling psychiatric symptoms.

Published in European Medical Journal

ISSN: 2397-6764 (Online)
Publisher: European Medical Journal
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.emjreviews.com/therapeutic-area/european-medical-journal/

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