Eye and Brain (Oct 2024)

Accuracy of Diagnosing Optic Neuritis Using DANTE T1-SPACE Imaging

  • Shimada A,
  • Suda K,
  • Nakano E,
  • Tagawa M,
  • Miyata M,
  • Kashii S,
  • Hinoda T,
  • Fushimi Y,
  • Kimura K,
  • Nishigori R,
  • Ahn S,
  • Grinstead J,
  • Tsujikawa A

Journal volume & issue
Vol. Volume 16
pp. 65 – 73

Abstract

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Ayaka Shimada,1,2 Kenji Suda,1 Eri Nakano,1 Miho Tagawa,1 Manabu Miyata,1 Satoshi Kashii,1 Takuya Hinoda,3 Yasutaka Fushimi,3 Kimitoshi Kimura,4 Ryusei Nishigori,4 Sinyeob Ahn,5 John Grinstead,6 Akitaka Tsujikawa1 1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan; 2Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan; 3Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; 4Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan; 5MR Research and Development, Siemens Healthineers, San Francisco, CA, USA; 6MR Research and Development, Siemens Healthineers, Portland, OR, USACorrespondence: Kenji Suda, Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shougoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan, Tel +81-75-751-3248, Fax +81-75-752-0933, Email [email protected]: To evaluate the use of delay alternating with nutation for tailored excitation-prepared T1-weighted turbo spin echo (DANTE T1-SPACE) imaging for diagnosing optic neuritis and to analyze its correlation with clinical findings before and after treatment.Patients and Methods: Patients diagnosed with optic neuritis or non-arteritic anterior ischemic optic neuropathy (NA-AION) were evaluated at the Ophthalmology Department of Kyoto University Hospital. All patients underwent magnetic resonance (MR) studies before treatment initiation and ophthalmic examinations before and after treatment. Three ophthalmologists independently reviewed the MR scans for abnormalities. The magnetic resonance imaging (MRI) assessments included post-contrast DANTE T1-SPACE, post-contrast volumetric interpolated breath-hold examination (VIBE), and short T1 inversion recovery (STIR) scans. The presence of abnormalities in each sequence was determined.Results: Of 36 eyes from 30 patients, 21 eyes from 17 patients were diagnosed with optic neuritis, and 15 eyes from 13 patients were diagnosed with NA-AION. DANTE T1-SPACE sequences showed better sensitivity for detecting optic neuritis than STIR sequences (100% vs 67%, p = 0.009). VIBE images did not confirm enhancement of lesions in some cases with optic neuritis. No differences were observed among the sequences for NA-AION. Lesion length evaluated by DANTE T1-SPACE sequences was associated with circumpapillary retinal nerve fiber layer thickness at the initial visit, eye pain, and the time interval from symptom onset to MRI scan.Conclusion: Contrast-enhanced DANTE T1-SPACE was better than other sequences of MRI for diagnosing optic neuritis.Keywords: Optic neuritis, magnetic resonance imaging, retinal nerve fiber layer, visual field test

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