Clinical Value of Inflammatory Bowel Disease Symptom Inventory in Evaluating the Activity of Inflammatory Bowel Disease

Abstract

Background Foreign studies have shown that the Inflammatory Bowel Disease Symptom Inventory (IBDSI) can be used for self-assessment of disease activity in patients with inflammatory bowel disease (IBD) , but the scale has not yet been validated in China. Objective To study the value of IBDSI in assessing the activity of patients with either ulcerative colitis (UC) or Crohn's disease (CD) . Methods A total of 102 patients with IBD who were hospitalized in the Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University from April 2020 to August 2021 were selected, including 59 patients with UC and 43 patients with CD. The activity of UC was assessed using Modified Mayo score and the activity of CD was assessed using CDAI score, respectively. Chinese version of the IBDSI translated by the gastroenterologist of our hospital was filled by patients in the next morning after admission. Spearman rank correlation analysis was used to analyze the correlation between IBDSI and each subscale score and Modified Mayo score, CDAI score and laboratory test indexes. The receiver operating characteristic curve (ROC curve) of IBDSI and its sub-items (including intestinal symptoms, abdominal discomfort, fatigue, intestinal complications, systemic complications) was drawn to evaluate the disease activity of UC and CD. Results The Modified Mayo score of 59 UC patients: 1 case was clinically relieved, 8 cases were mild, 46 cases were moderate, and 4 cases were severe; IBDSI score was (26.27±15.16) . The CDAI scores of 43 CD patients: 11 cases were in remission, 8 cases were mild, 22 cases were moderate, and 2 cases were severe; IBDSI score was (26.95±16.19) . Spearman rank correlation analysis showed that total IBDSI score, intestinal symptom score, abdominal discomfort score and fatigue score were positively correlated with Modified Mayo score in UC patients (P<0.05) . In CD patients, total IBDSI score, intestinal symptom score, abdominal discomfort score, fatigue score and systemic complication score were significantly positively associated with CDAI score (P<0.05) . The area under the ROC curve (AUC) of total IBDSI score, intestinal symptom score, abdominal discomfort score, and fatigue score to assess disease activity of UC were 0.829, 0.836, 0.710 and 0.786, respectively (P<0.05) .In patients with CD, the AUC of total IBDSI score, intestinal symptom score, abdominal discomfort score, fatigue and systemic complication score were 0.911, 0.806, 0.785, 0.867 and 0.734, respectively (P<0.05) . Conclusion IBDSI and its sub-scores have a certain correlation with the disease activity of inflammatory bowel disease (including UC and CD) .

Keywords

• inflammatory bowel diseases|inflammatory bowel disease symptom inventory|colitis, ulcerative|crohn disease|forecasting