New drugs for pharmacological extension of replicative life span in normal and progeroid cells

Abstract

Remedies to extend life span Two drugs were discovered that can extend the life spans of normally aged human cells and thus potentially slow human aging. The anti-aging drugs were identified using a novel method that screens drugs across a two-dimensional endpoint space of senescence-associated galactosidase activity as a general axis of aging and ATP as an axis representing proliferation. The two most potent substances were, likely more than coincidentally, electrons carriers that transfer electrons from NAD(P)H to molecules and cellular structures that demand reducing power to repair oxidative damage that accumulates with aging. Treatment of single cells and whole organisms with these new anti-aging drugs increased their lifespans. The mechanism of the drug action may advance our understanding of the complex, yet resolvable, biological process of aging.