PLoS ONE (Jan 2021)

Changes in central venous-to-arterial carbon dioxide tension induced by fluid bolus in critically ill patients.

  • Charalampos Pierrakos,
  • David De Bels,
  • Thomas Nguyen,
  • Dimitrios Velissaris,
  • Rachid Attou,
  • Jacques Devriendt,
  • Patrick M Honore,
  • Fabio Silvio Taccone,
  • Daniel De Backer

DOI
https://doi.org/10.1371/journal.pone.0257314
Journal volume & issue
Vol. 16, no. 9
p. e0257314

Abstract

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BackgroundIn this prospective observational study, we evaluated the effects of fluid bolus (FB) on venous-to-arterial carbon dioxide tension (PvaCO2) in 42 adult critically ill patients with pre-infusion PvaCO2 > 6 mmHg.ResultsFB caused a decrease in PvaCO2, from 8.7 [7.6-10.9] mmHg to 6.9 [5.8-8.6] mmHg (p ConclusionsFluid bolus decreased abnormal PvaCO2 levels independently of pre-infusion CI. Low baseline PvaCO2 values suggest that a positive response to FB is unlikely.