Safety of Monoclonal Antibodies in Children Affected by SARS-CoV-2 Infection

Lorenza Romani; Francesca Ippolita Calò Carducci; Sara Chiurchiù; Laura Cursi; Maia De Luca; Martina Di Giuseppe; Andrzej Krzysztofiak; Laura Lancella; Paolo Palma; Leonardo Vallesi; Tiziana Corsetti; Andrea Campana; Emanuele Nicastri; Paolo Rossi; Stefania Bernardi

doi:10.3390/children9030369

Children (Mar 2022)

Safety of Monoclonal Antibodies in Children Affected by SARS-CoV-2 Infection

Lorenza Romani,
Francesca Ippolita Calò Carducci,
Sara Chiurchiù,
Laura Cursi,
Maia De Luca,
Martina Di Giuseppe,
Andrzej Krzysztofiak,
Laura Lancella,
Paolo Palma,
Leonardo Vallesi,
Tiziana Corsetti,
Andrea Campana,
Emanuele Nicastri,
Paolo Rossi,
Stefania Bernardi

Affiliations

Lorenza Romani: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Francesca Ippolita Calò Carducci: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Sara Chiurchiù: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Laura Cursi: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Maia De Luca: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Martina Di Giuseppe: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Andrzej Krzysztofiak: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Laura Lancella: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Paolo Palma: Research Unit of Congenital and Perinatal Infections, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Leonardo Vallesi: Hospital Pharmacy Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Tiziana Corsetti: Hospital Pharmacy Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Andrea Campana: Department of Pediatrics, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Emanuele Nicastri: National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy
Paolo Rossi: Chair of Pediatrics, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
Stefania Bernardi: Immunology and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy

DOI: https://doi.org/10.3390/children9030369
Journal volume & issue: Vol. 9, no. 3
p. 369

Abstract

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Monoclonal antibody therapies for COVID-19 have been frequently used in adults, whereas there are little data regarding the safety or efficacy of monoclonal antibody treatments in pediatric patients affected by COVID-19. We report our experience in the administration of mAb as a treatment for SARS-CoV-2 infection in children aged from 24 days to 18 years old.

Published in Children

ISSN: 2227-9067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://www.mdpi.com/journal/children

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Abstract

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