Nature Communications (Jun 2019)
Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
- Dmitry Shungin,
- Simon Haworth,
- Kimon Divaris,
- Cary S. Agler,
- Yoichiro Kamatani,
- Myoung Keun Lee,
- Kelsey Grinde,
- George Hindy,
- Viivi Alaraudanjoki,
- Paula Pesonen,
- Alexander Teumer,
- Birte Holtfreter,
- Saori Sakaue,
- Jun Hirata,
- Yau-Hua Yu,
- Paul M. Ridker,
- Franco Giulianini,
- Daniel I. Chasman,
- Patrik K. E. Magnusson,
- Takeaki Sudo,
- Yukinori Okada,
- Uwe Völker,
- Thomas Kocher,
- Vuokko Anttonen,
- Marja-Liisa Laitala,
- Marju Orho-Melander,
- Tamar Sofer,
- John R. Shaffer,
- Alexandre Vieira,
- Mary L. Marazita,
- Michiaki Kubo,
- Yasushi Furuichi,
- Kari E. North,
- Steve Offenbacher,
- Erik Ingelsson,
- Paul W. Franks,
- Nicholas J. Timpson,
- Ingegerd Johansson
Affiliations
- Dmitry Shungin
- Department of Odontology, Umeå University
- Simon Haworth
- Medical Research Council Integrative Epidemiology Unit, Bristol Medical School
- Kimon Divaris
- Department of Pediatric Dentistry, School of Dentistry, University of North Carolina
- Cary S. Agler
- Department of Oral and Craniofacial Health Sciences, University of North Carolina
- Yoichiro Kamatani
- RIKEN Center for Integrative Medical Sciences
- Myoung Keun Lee
- Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh
- Kelsey Grinde
- Department of Biostatistics, University of Washington
- George Hindy
- Lund University
- Viivi Alaraudanjoki
- Research Unit of Oral Health Sciences University of Oulu
- Paula Pesonen
- Infrastructure for Population Studies, Faculty of Medicine, University of Oulu
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Birte Holtfreter
- Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine Greifswald
- Saori Sakaue
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Jun Hirata
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Yau-Hua Yu
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Paul M. Ridker
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Franco Giulianini
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Daniel I. Chasman
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Patrik K. E. Magnusson
- Department of Medical Epidemiology and Biostatistics, Karolinska Instituet
- Takeaki Sudo
- Department of Periodontology, Graduate School of Medical and Dental Science of Tokyo Medical and Dental University
- Yukinori Okada
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Uwe Völker
- Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
- Thomas Kocher
- Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine Greifswald
- Vuokko Anttonen
- Research Unit of Oral Health Sciences University of Oulu
- Marja-Liisa Laitala
- Research Unit of Oral Health Sciences University of Oulu
- Marju Orho-Melander
- Lund University
- Tamar Sofer
- Harvard Medical School
- John R. Shaffer
- Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh
- Alexandre Vieira
- Department of Oral Biology, University of Pittsburgh
- Mary L. Marazita
- Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Yasushi Furuichi
- Department of Oral Rehabilitation, Division of Periodontology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido
- Kari E. North
- Department of Epidemiology, University of North Carolina
- Steve Offenbacher
- Department of Periodontology, University of North Carolina
- Erik Ingelsson
- Department of Medicine, Stanford University School of Medicine
- Paul W. Franks
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University
- Nicholas J. Timpson
- Medical Research Council Integrative Epidemiology Unit, Bristol Medical School
- Ingegerd Johansson
- Department of Odontology, Umeå University
- DOI
- https://doi.org/10.1038/s41467-019-10630-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.
