Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy

Jing Liu; Zhihao Zhao; Nasha Qiu; Quan Zhou; Guowei Wang; Haiping Jiang; Ying Piao; Zhuxian Zhou; Jianbin Tang; Youqing Shen

doi:10.1038/s41467-021-22407-6

Nature Communications (Apr 2021)

Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy

Jing Liu,
Zhihao Zhao,
Nasha Qiu,
Quan Zhou,
Guowei Wang,
Haiping Jiang,
Ying Piao,
Zhuxian Zhou,
Jianbin Tang,
Youqing Shen

Affiliations

Jing Liu: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Zhihao Zhao: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Nasha Qiu: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Quan Zhou: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Guowei Wang: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Haiping Jiang: Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University
Ying Piao: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Zhuxian Zhou: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Jianbin Tang: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Youqing Shen: Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University

DOI: https://doi.org/10.1038/s41467-021-22407-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Some chemotherapeutic drugs, such as doxorubicin, induce immunogenic cell death (ICD) and promote anti-tumor immune responses. Here the authors report that the histone demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX1) reduces the expression of PD-L1 in cancer cells and enhances doxorubicin-induced ICD, promoting T cell infiltration and reducing tumor growth in preclinical models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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