Bio-degradable highly fluorescent conjugated polymer nanoparticles for bio-medical imaging applications

Tatjana Repenko; Anne Rix; Simon Ludwanowski; Dennis Go; Fabian Kiessling; Wiltrud Lederle; Alexander J. C. Kuehne

doi:10.1038/s41467-017-00545-0

Nature Communications (Sep 2017)

Bio-degradable highly fluorescent conjugated polymer nanoparticles for bio-medical imaging applications

Tatjana Repenko,
Anne Rix,
Simon Ludwanowski,
Dennis Go,
Fabian Kiessling,
Wiltrud Lederle,
Alexander J. C. Kuehne

Affiliations

Tatjana Repenko: DWI-Leibniz Institute for Interactive Materials, RWTH Aachen University
Anne Rix: Institute for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH Aachen University
Simon Ludwanowski: DWI-Leibniz Institute for Interactive Materials, RWTH Aachen University
Dennis Go: DWI-Leibniz Institute for Interactive Materials, RWTH Aachen University
Fabian Kiessling: Institute for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH Aachen University
Wiltrud Lederle: Institute for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH Aachen University
Alexander J. C. Kuehne: DWI-Leibniz Institute for Interactive Materials, RWTH Aachen University

DOI: https://doi.org/10.1038/s41467-017-00545-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Conjugated polymer nanoparticles have been applied for biological fluorescence imaging in cell culture and in small animals, but cannot readily be excreted through the renal system. Here the authors show fully conjugated polymer nanoparticles based on imidazole units that can be bio-degraded by activated macrophages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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