Nature Communications (Oct 2018)

Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis

  • Fucheng Luo,
  • Amanda Phuong Tran,
  • Li Xin,
  • Chandrika Sanapala,
  • Bradley T. Lang,
  • Jerry Silver,
  • Yan Yang

DOI
https://doi.org/10.1038/s41467-018-06505-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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Demyelination failure in multiple sclerosis (MS) may contribute to the disease progression. This study shows that chondroitin sulfate proteoglycans (CSPGs) can inhibit remyelination in an animal model of MS via CSPG binding with the receptor PTPσ on oligodendrocyte progenitor cells, and disruption of this interaction can promote recovery in the animal models of MS.