A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity

Abstract

A new lignanamide (1), lyciumamide K, together with four known analogues (2–5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds 1–5 in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities. Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 ± 0.52. Thus, the new lignanamide may be a good source of bioavtive and protective compounds.

Keywords

• Lycium yunnanense Kuang
• lyciumamide K
• ECD calculations
• antioxidant activities
• oxygen radical absorbance capacity (ORAC) assay