SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection

Jernej Pušnik; Werner O. Monzon-Posadas; Jasmin Zorn; Kathrin Peters; Maximilian Baum; Hannah Proksch; Celina Beta Schlüter; Galit Alter; Tanja Menting; Hendrik Streeck

doi:10.1038/s41467-023-36250-4

Nature Communications (Feb 2023)

SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection

Jernej Pušnik,
Werner O. Monzon-Posadas,
Jasmin Zorn,
Kathrin Peters,
Maximilian Baum,
Hannah Proksch,
Celina Beta Schlüter,
Galit Alter,
Tanja Menting,
Hendrik Streeck

Affiliations

Jernej Pušnik: Institute of Virology, University Hospital Bonn
Werner O. Monzon-Posadas: Institute of Virology, University Hospital Bonn
Jasmin Zorn: Institute of Virology, University Hospital Bonn
Kathrin Peters: Institute of Virology, University Hospital Bonn
Maximilian Baum: Institute of Virology, University Hospital Bonn
Hannah Proksch: Institute of Virology, University Hospital Bonn
Celina Beta Schlüter: Institute of Virology, University Hospital Bonn
Galit Alter: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital
Tanja Menting: Occupational Medicine Department, University Hospital Bonn
Hendrik Streeck: Institute of Virology, University Hospital Bonn

DOI: https://doi.org/10.1038/s41467-023-36250-4
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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SARS-CoV-2 vaccination and breakthrough infection scenarios increasingly differ on an individual and population level. Here, the authors analyzed humoral and cellular immune responses in various antigen exposure scenarios and identified combinations providing enhanced immune response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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