Characterization and pathogenicity of infectious bursal disease virus in Southern China

Zixian Chen; Jiamin Lian; Zhishan Liang; Mei Leng; Wencheng Lin; Feng Chen

Poultry Science (Oct 2022)

Characterization and pathogenicity of infectious bursal disease virus in Southern China

Zixian Chen,
Jiamin Lian,
Zhishan Liang,
Mei Leng,
Wencheng Lin,
Feng Chen

Affiliations

Zixian Chen: College of Animal Science, South China Agricultural University, Guangzhou 510642, P R China
Jiamin Lian: College of Animal Science, South China Agricultural University, Guangzhou 510642, P R China
Zhishan Liang: College of Animal Science, South China Agricultural University, Guangzhou 510642, P R China
Mei Leng: College of Animal Science, South China Agricultural University, Guangzhou 510642, P R China
Wencheng Lin: College of Animal Science, South China Agricultural University, Guangzhou 510642, P R China; Guangdong Provincial Animal Virus Vector Vaccine Engineering Technology Research Center, South China Agricultural University, Guangzhou 510642, P R China
Feng Chen: College of Animal Science, South China Agricultural University, Guangzhou 510642, P R China; Guangdong Provincial Animal Virus Vector Vaccine Engineering Technology Research Center, South China Agricultural University, Guangzhou 510642, P R China; Corresponding author:

Journal volume & issue: Vol. 101, no. 10
p. 102018

Abstract

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ABSTRACT: Infectious bursal disease virus (IBDV) is a widespread pathogen that induces immunosuppression in 3 to 6-wk-old chickens, casuing great threaten to the poultry industry worldwide. Previously, the very virulent IBDV (vvIBDV) was mainly prevalent in China. In recent years, the novel variant IBDV (nvIBDV) occurred in China. In this study, we isolated 30 IBDV strains of IBDV from vaccinated chicken flocks in 8 provinces of southern China. Among these isolates, vvIBDV group (13/30) and nvIBDV group (17/30) were identified according to the genome sequencing and phylogenic analysis. Moreover, HB2021-5 and GD2021-17 have pathologic characteristics with severe bursal lesions, as evidenced by necrosis, depletion of lymphocytes, and follicle atrophy. Our findings provide an important reference for understanding the epidemiological status and the evolution of IBDV.

Published in Poultry Science

ISSN: 0032-5791 (Print); 1525-3171 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Agriculture: Animal culture
Website: https://www.journals.elsevier.com/poultry-science

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