One-Step Preparation of Adhesive Composite Hydrogels through Fast and Simultaneous In Situ Formation of Silver Nanoparticles and Crosslinking
Yi Li,
Yunchao Xiao,
Man Xi,
Guibin Li,
Yang Jiang
Affiliations
Yi Li
College of Materials and Textile Engineering & Nanotechnology Research Institute (NRI), Jiaxing University, Jiaxing 314001, China
Yunchao Xiao
College of Materials and Textile Engineering & Nanotechnology Research Institute (NRI), Jiaxing University, Jiaxing 314001, China
Man Xi
College of Materials and Textile Engineering & Nanotechnology Research Institute (NRI), Jiaxing University, Jiaxing 314001, China
Guibin Li
Key Laboratory of Medical Electronics and Digital Health of Zhejiang Province, Engineering Research Center of Intelligent Human Health Situation Awareness of Zhejiang Province, Jiaxing University, Jiaxing 314001, China
Yang Jiang
College of Materials and Textile Engineering & Nanotechnology Research Institute (NRI), Jiaxing University, Jiaxing 314001, China
In this study, a series of gelatin/silver nanoparticles (AgNPs) composite hydrogels are prepared for the first time through the facile in situ formation of AgNPs. AgNPs, which are formed by reducing Ag+ using dopamine-conjugated gelatins. These can simultaneously crosslink gelatin molecules, thus generating three-dimentional and porous hydrogels. The gelation time and pore sizes of these composite hydrogels can be controlled by controlling the feeding concentration of AgNO3 and weight content of gelatin in water, respectively. The feeding concentration of AgNO3 also has an effect on the equilibrium swelling ratio of the hydrogels. Moreover, these composite hydrogels, with a controllable gelation time and in situ forming ability, exhibit good adhesive properties and can be used as drug-release depots.
