Cytomegalovirus genetic diversity

Abstract

The review article considers modern data of genetic variety cytomegalovirus , circulating in the world, various approaches to genotyping of cytomegalovirus clinical isolates are represented, the characteristic of basic polymorphic genes, used for strains differentiation is given, the linkage between the strain specific genotypes and the clinical manifestations of cytomegalovirus infection in patients of highrisk groups is described. The information of cytomegalovirus genotypes is necessary for realization cytomegalovirus infection-epidemiological surveillance and development of effective vaccine.

Keywords

• cytomegalovirus
• viral genotypes
• gene polymorphisms
• cmv genotype distribution