Long non-coding RNAs regulate drug resistance in cancer

Kaisheng Liu; Lin Gao; Xiaoshi Ma; Juan-Juan Huang; Juan Chen; Leli Zeng; Charles R. Ashby; Chang Zou; Zhe-Sheng Chen

doi:10.1186/s12943-020-01162-0

Molecular Cancer (Mar 2020)

Long non-coding RNAs regulate drug resistance in cancer

Kaisheng Liu,
Lin Gao,
Xiaoshi Ma,
Juan-Juan Huang,
Juan Chen,
Leli Zeng,
Charles R. Ashby,
Chang Zou,
Zhe-Sheng Chen

Affiliations

Kaisheng Liu: The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital
Lin Gao: The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital
Xiaoshi Ma: The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital
Juan-Juan Huang: Department of Physics, Technical University of Munich
Juan Chen: The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital
Leli Zeng: College of Pharmacy and Health Sciences, St. John’s University, Queens
Charles R. Ashby: College of Pharmacy and Health Sciences, St. John’s University, Queens
Chang Zou: The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital
Zhe-Sheng Chen: College of Pharmacy and Health Sciences, St. John’s University, Queens

DOI: https://doi.org/10.1186/s12943-020-01162-0
Journal volume & issue: Vol. 19, no. 1
pp. 1 – 13

Abstract

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Abstract Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance.

Published in Molecular Cancer

ISSN: 1476-4598 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://molecular-cancer.biomedcentral.com/

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Abstract

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