Association of polymorphism rs1859962 with prostate cancer in Iranian men

Abstract

Introduction: One of the most common malignancies in men is prostate cancer. According to genome-wide association studies (GWAS), some single nucleotide polymorphisms (SNPs) are likely factors for prostate cancer. Objective: The aim of this study was to investigate the association between the rs1859962 polymorphism and prostate cancer risk. Material & Methods: This case-control study was conducted on 172 peripheral blood samples, including 72 cases of prostate cancer and 100 control subjects with BPH. The Tetra - ARMs PCR technique was used for SNP genotyping. Results: The results showed that the GG genotype of the rs185996 polymorphism had a significant association with prostate cancer risk in the recessive model (P=0.022; OR=3.426; 95% CI=1.135-10.344). According to the results of the dominant and additive models, there is no risk of prostate cancer in these genetic models. The polymorphism Rs1859962 was correlated with GS≥8 (P=0.021; OR=2.088; 95%CI=1.11-3.928), EPE (P=0.002) and PSA>10 (P=0.016; OR=2.133; 95%CI=1.44-3.978). Discussion & Conclusion: Our results suggest that the rs1859962 polymorphism is associated with prostate cancer risk in a recessive model and can be considered as a potential biomarker for screening prostate cancer patients.

Keywords

• rs1859962
• single nucleotide polymorphism
• prostate cancer