Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKD-EPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study

Abstract

Purpose: Serum cystatin C level is a specific marker to estimate the glomerular filtration rate (GFR). Due to this specificity, we assume that GFR estimations based on cystatin C have higher diagnostic performances than GFR estimations using other biomarkers. In this study, we aimed to compared the diagnostic performances of CKD-EPI cystatin C equation, CKD-EPI creatinine equation and 24-hour creatinine clearance to estimate GFR. Materials and Methods: A total of 130 participants who consisting of 101 acute and chronic renal disease patients and 29 healthy volunteers, who applied to the Nephrology Clinic, have been included in our study. Their urine creatinine levels and serum creatinine levels were measured by the colorimetric-Jaffe method, and cystatin C was by the nephelometric method. Results: There was a statistically significant relationship between CKD-EPI cystatin C, between CKD-EPI creatinine and standard creatinine clearance. The Area Under the Receiver Operating Characteristics curve (AUROC) was found to be 1, 0.995, and 0.954 respectively. Conclusion: According to the results, we think that serum cystatin C levels will present earlier findings in GFR decrease and may be a more effective marker than serum creatinine and standard creatinine clearance in the early period.

Keywords

• cystatin c, ckd
• ckd-epi
• glomerular filtration rate
• creatinine
• kidney failure