Refractory ulcers of both legs with psoriasis vulgaris successfully treated with dehydrated human amnion/chorion membrane: A case report
Soma Nakaso,
Hyakuzoh Ueda,
Chiemi Kaku,
Yuki Ideguchi,
Aya Miyama,
Rei Ogawa
Affiliations
Soma Nakaso
Department of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan; Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan; Corresponding author.
Hyakuzoh Ueda
Department of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan; Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan
Chiemi Kaku
Department of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan; Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan
Yuki Ideguchi
Department of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan; Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan
Aya Miyama
Department of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan; Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan
Rei Ogawa
Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan
Patients with psoriasis are particularly susceptible to skin damage and secondary infections due to impaired skin defenses and chronic inflammation. This case report describes an 80-year-old male with psoriasis vulgaris and a refractory venous stasis ulcer that successfully achieved epithelialization following treatment with dehydrated human amnion/chorion membrane (dHACM; EPIFIX®). Despite initial management involving infection control and wound debridement, the ulcer exhibited minimal improvement until the application of dHACM. Within 4 wk, substantial wound contraction and epithelialization were achieved, eliminating the need for skin grafting. The regenerative properties of dHACM, employed in accordance with the TIMERS framework, facilitated effective wound healing through a minimally invasive approach. This case represents the first documented use of dHACM for a venous ulcer in a patient with psoriasis vulgaris, underscoring its potential as an innovative therapeutic option for managing chronic ulcers.
