Nature Communications (May 2018)
High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics
- Thomas Mager,
- David Lopez de la Morena,
- Verena Senn,
- Johannes Schlotte,
- Anna D´Errico,
- Katrin Feldbauer,
- Christian Wrobel,
- Sangyong Jung,
- Kai Bodensiek,
- Vladan Rankovic,
- Lorcan Browne,
- Antoine Huet,
- Josephine Jüttner,
- Phillip G. Wood,
- Johannes J. Letzkus,
- Tobias Moser,
- Ernst Bamberg
Affiliations
- Thomas Mager
- Department of Biophysical Chemistry, Max Planck Institute of Biophysics
- David Lopez de la Morena
- Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
- Verena Senn
- Neocortical Circuits Lab, Max Planck Institute for Brain Research
- Johannes Schlotte
- Department of Biophysical Chemistry, Max Planck Institute of Biophysics
- Anna D´Errico
- Department of Biophysical Chemistry, Max Planck Institute of Biophysics
- Katrin Feldbauer
- Department of Biophysical Chemistry, Max Planck Institute of Biophysics
- Christian Wrobel
- Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
- Sangyong Jung
- Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
- Kai Bodensiek
- Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
- Vladan Rankovic
- Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
- Lorcan Browne
- Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
- Antoine Huet
- Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
- Josephine Jüttner
- Friedrich Miescher Institute for Biomedical Research
- Phillip G. Wood
- Department of Biophysical Chemistry, Max Planck Institute of Biophysics
- Johannes J. Letzkus
- Neocortical Circuits Lab, Max Planck Institute for Brain Research
- Tobias Moser
- Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
- Ernst Bamberg
- Department of Biophysical Chemistry, Max Planck Institute of Biophysics
- DOI
- https://doi.org/10.1038/s41467-018-04146-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Optogenetic applications would benefit from channelrhodopsins (ChRs) with faster photostimulation, increased tissue transparency and lower phototoxicity. Here, the authors develop fast red-shifted ChR variants and show the abilities for temporal precise spiking of cerebral interneurons and restoring auditory activity in deaf mice.
