DETERMINATION OF PHENOLIC COMPOUNDS IN PRUNUS DOMESTICA FRUITS EXTRACT AND ITS PHARMACOLOGICAL ACTIVITY

Shahm B. Mohammed; Taras V. Upyr; Olga M. Shapoval; Larysa V. Lenchyk; Kaloyan Georgiev

doi:10.5272/jimab.2019252.2589

Journal of IMAB (Jun 2019)

DETERMINATION OF PHENOLIC COMPOUNDS IN PRUNUS DOMESTICA FRUITS EXTRACT AND ITS PHARMACOLOGICAL ACTIVITY

Shahm B. Mohammed,
Taras V. Upyr,
Olga M. Shapoval,
Larysa V. Lenchyk,
Kaloyan Georgiev

Affiliations

Shahm B. Mohammed: Department of Chemistry of Natural Compounds, National University of Pharmacy, Kharkiv, Ukraine,
Taras V. Upyr: Department of Pharmacognosy, National University of Pharmacy, Kharkiv, Ukraine
Olga M. Shapoval: Department of Pharmacology and Prescription writing, Kharkiv National Medical University Kharkiv, Ukraine
Larysa V. Lenchyk: Department of Chemistry of Natural Compounds, National University of Pharmacy, Kharkiv, Ukraine,
Kaloyan Georgiev: Department of Pharmaceutical technologies, Faculty of pharmacy, Medical University of Varna, Bulgaria.

DOI: https://doi.org/10.5272/jimab.2019252.2589
Journal volume & issue: Vol. 25, no. 2
pp. 2589 – 2594

Abstract

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Qualitative composition and content of phenolic compounds in the liquid extract obtained from plum fruits have been studied. Five phenolic substances were found, as gallic acid, three hydroxycinnamic acids and rutin. The dominant substance was neochlorogenic acid (2320±42 mg/kg). Phenolic substances were identified in the extract and their amount determined by HPLC. Diuretic activity as diurnal spontaneous diuresis and forced diuresis, hypouricosemic and the membrane-stabilizing effects of plum liquid extract and its influence on the rheological properties of blood were studied.

Published in Journal of IMAB

ISSN: 1312-773X (Online)
Publisher: Peytchinski Publishing
Country of publisher: Bulgaria
LCC subjects: Medicine: Dentistry; Medicine: Medicine (General)
Website: http://www.journal-imab-bg.org/

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Abstract

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