Nature Communications (Jun 2019)
DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
- Giulia Favaro,
- Vanina Romanello,
- Tatiana Varanita,
- Maria Andrea Desbats,
- Valeria Morbidoni,
- Caterina Tezze,
- Mattia Albiero,
- Marta Canato,
- Gaia Gherardi,
- Diego De Stefani,
- Cristina Mammucari,
- Bert Blaauw,
- Simona Boncompagni,
- Feliciano Protasi,
- Carlo Reggiani,
- Luca Scorrano,
- Leonardo Salviati,
- Marco Sandri
Affiliations
- Giulia Favaro
- Venetian Institute of Molecular Medicine
- Vanina Romanello
- Venetian Institute of Molecular Medicine
- Tatiana Varanita
- Department of Biology, University of Padova
- Maria Andrea Desbats
- Clinical Genetics Unit, Department of Woman and Child Health, University of Padova
- Valeria Morbidoni
- Clinical Genetics Unit, Department of Woman and Child Health, University of Padova
- Caterina Tezze
- Venetian Institute of Molecular Medicine
- Mattia Albiero
- Venetian Institute of Molecular Medicine
- Marta Canato
- Department of Biomedical Science, University of Padova
- Gaia Gherardi
- Department of Biomedical Science, University of Padova
- Diego De Stefani
- Department of Biomedical Science, University of Padova
- Cristina Mammucari
- Department of Biomedical Science, University of Padova
- Bert Blaauw
- Venetian Institute of Molecular Medicine
- Simona Boncompagni
- Center for Research on Ageing and Translational Medicine (CeSI-MeT)), via Luigi Polacchi, University G. d’ Annunzio
- Feliciano Protasi
- Center for Research on Ageing and Translational Medicine (CeSI-MeT)), via Luigi Polacchi, University G. d’ Annunzio
- Carlo Reggiani
- Department of Biomedical Science, University of Padova
- Luca Scorrano
- Venetian Institute of Molecular Medicine
- Leonardo Salviati
- Clinical Genetics Unit, Department of Woman and Child Health, University of Padova
- Marco Sandri
- Venetian Institute of Molecular Medicine
- DOI
- https://doi.org/10.1038/s41467-019-10226-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Muscle loss is associated with altered expression of proteins involved in mitochondrial homeostasis, but whether this is causative remains unclear. Here, the authors show that genetic ablation of the pro-fission protein DRP1 leads to accumulation of abnormal mitochondria that induce muscle atrophy by altering Ca2+ homeostasis and cellular stress responses.
