PLoS ONE (Jan 2015)

Epidemiology and clinical features of pulmonary nontuberculous mycobacteriosis in Nagasaki, Japan.

  • Shotaro Ide,
  • Shigeki Nakamura,
  • Yoshihiro Yamamoto,
  • Yoshihisa Kohno,
  • Yuichi Fukuda,
  • Hideki Ikeda,
  • Eisuke Sasaki,
  • Katsunori Yanagihara,
  • Yasuhito Higashiyama,
  • Kohji Hashiguchi,
  • Yoji Futsuki,
  • Yuichi Inoue,
  • Kiyoyasu Fukushima,
  • Naofumi Suyama,
  • Shigeru Kohno

DOI
https://doi.org/10.1371/journal.pone.0128304
Journal volume & issue
Vol. 10, no. 5
p. e0128304

Abstract

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Background and objectivesRecent reports indicate that the incidence of nontuberculous mycobacterial-lung disease (NTM-LD) is increasing. This study aimed to investigate the epidemiology and clinical features of NTM-LD patients in Nagasaki prefecture, Japan to identify the negative prognostic factors for NTM-LD in Japan.MethodsThe medical records of patients newly diagnosed with NTM-LD in eleven hospitals in Nagasaki prefecture between January 2001 and February 2010 were reviewed. Data regarding the annual population of each region and the incidence of all forms of tuberculosis were collected to assess geographic variations in NTM-LD incidence, isolates, and radiological features.ResultsA total 975 patients were diagnosed with NTM-LD. The incidence increased over the study period and reached 11.0 and 10.1 per 100,000 population in 2008 and 2009, respectively. M. intracellulare was the most common pathogen in the southern region, and M. avium most common in other regions. The most common radiographic pattern was the nodular-bronchiectatic pattern. Age >60 years, body mass index ConclusionsThe incidence of NTM-LD has been increasing in Nagasaki prefecture. The isolates and radiographic features of patients vary markedly by region.