Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation

Dingfeng Li; Juan Zhang; Ming Wang; Xiaohui Li; Huarui Gong; Huiping Tang; Lin Chen; Lili Wan; Qiang Liu

doi:10.1038/s41467-018-04072-4

Nature Communications (Apr 2018)

Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation

Dingfeng Li,
Juan Zhang,
Ming Wang,
Xiaohui Li,
Huarui Gong,
Huiping Tang,
Lin Chen,
Lili Wan,
Qiang Liu

Affiliations

Dingfeng Li: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Juan Zhang: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Ming Wang: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Xiaohui Li: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Huarui Gong: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Huiping Tang: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Lin Chen: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Lili Wan: Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, School of Medicine, University of Pennsylvania
Qiang Liu: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-018-04072-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Non-coding RNAs have been shown to be key components in translational regulation. Here the authors characterize long nucleolus specific lncRNA termed LoNA, identified to play a role in protein biosynthesis by inhibiting rRNA production and ribosome biosynthesis in nucleoli.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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