PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

Jingliang Zhang; Chenyu Zhang; Xiaoling Chen; Bingwei Wang; Weining Ma; Yang Yang; Ruimao Zheng; Zhuo Huang

doi:10.1038/s42003-021-01748-4

Communications Biology (Mar 2021)

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

Jingliang Zhang,
Chenyu Zhang,
Xiaoling Chen,
Bingwei Wang,
Weining Ma,
Yang Yang,
Ruimao Zheng,
Zhuo Huang

Affiliations

Jingliang Zhang: State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center
Chenyu Zhang: Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University Health Science Center
Xiaoling Chen: State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center
Bingwei Wang: Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University Health Science Center
Weining Ma: Department of Neurology, Shengjing Hospital Affiliated to China Medical University
Yang Yang: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy
Ruimao Zheng: Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University Health Science Center
Zhuo Huang: State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center

DOI: https://doi.org/10.1038/s42003-021-01748-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Jingliang Zhang et al. examine how dysfunctional PKA signaling impacts neuronal activity and seizure susceptibility in a mouse model of temporal lobe epilepsy. Their data suggest that autophosphorylation of the RIIβ subunit regulates neuronal excitability, and may act as a future therapeutic target.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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