Nature Communications (Aug 2018)

Structure of the mouse TRPC4 ion channel

  • Jingjing Duan,
  • Jian Li,
  • Bo Zeng,
  • Gui-Lan Chen,
  • Xiaogang Peng,
  • Yixing Zhang,
  • Jianbin Wang,
  • David E. Clapham,
  • Zongli Li,
  • Jin Zhang

DOI
https://doi.org/10.1038/s41467-018-05247-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Members of the transient receptor potential (TRP) ion channels conduct cations into cells upon activation by a variety of signals. Here authors present the cryo-EM structure of TRPC4 in its unliganded (apo) state, which provides molecular insights into TRPC4's ion selectivity and TPR channel evolution.