Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum

Wanying Lu; Guoliang Zhu; Weize Yuan; Zhaoxi Han; Huanqin Dai; Mostafa Basiony; Lixin Zhang; Xueting Liu; Tom Hsiang; Jingyu Zhang

Synthetic and Systems Biotechnology (Dec 2021)

Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum

Wanying Lu,
Guoliang Zhu,
Weize Yuan,
Zhaoxi Han,
Huanqin Dai,
Mostafa Basiony,
Lixin Zhang,
Xueting Liu,
Tom Hsiang,
Jingyu Zhang

Affiliations

Wanying Lu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Guoliang Zhu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Weize Yuan: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Zhaoxi Han: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Huanqin Dai: The State Key Laboratory of Mycology (SKLM), Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
Mostafa Basiony: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Lixin Zhang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Xueting Liu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Tom Hsiang: School of Environmental Sciences, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada
Jingyu Zhang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Corresponding author.

Journal volume & issue: Vol. 6, no. 4
pp. 446 – 451

Abstract

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Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B (1 and 2), together with one previously characterized sesquiterpenoid lignoren (3) were identified. Structures of 1–3 were assigned by mass spectrometry and NMR spectroscopy. Their bioactivities were assessed against Staphylococcus epidermidis, S. aureus, and Methicillin-resistant S. aureus (MRSA). Compounds 1 and 2 exhibited weak antibacterial activity against S. epidermidis (MIC = 100 μM).

Published in Synthetic and Systems Biotechnology

ISSN: 2405-805X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/synthetic-and-systems-biotechnology/

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