Risk Factors of Postoperative Recurrence for Giant Cell Tumor of Bone

Abstract

Objective To investigate the relationship between the characteristics and postoperative recurrence of giant cell tumor (GCT) of bone. Methods A total of 451 patients followed up with GCT of bone undergoing surgical treatment were reviewed to analyze the association of the characteristics, including tumor location, operation method, Campanacci grade, pathological fracture and pulmonary metastasis, with the recurrence rate of GCT bone. Results The recurrence rate of GCT in the spine or pelvis was significantly higher than that around the knee (P 0.05). The pulmonary metastasis rate in the recurrence cases of GCT was significantly higher than that in no recurrence cases (P 0.05). Conclusion The surgical procedure affects the surgical boundary of GCT, which is closely related to the postoperative recurrence rate; the pulmonary metastasis rate of recurrent cases is significantly increased; adequate surgical boundaries for the surgical treatment of GCT may be essential to improve the prognosis of patients with GCT.

Keywords

• giant cell tumor of bone
• postoperative recurrence
• cause analysis
• surgical treatment