Frontiers in Immunology (Apr 2025)

The NF-κB signaling network in the life of T cells

  • Mark A. Daniels,
  • Mark A. Daniels,
  • Emma Teixeiro,
  • Emma Teixeiro

DOI
https://doi.org/10.3389/fimmu.2025.1559494
Journal volume & issue
Vol. 16

Abstract

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NF-κB is a crucial transcription factor in lymphocyte signaling. It is activated by environmental cues that drive lymphocyte differentiation to combat infections and cancer. As a key player in inflammation, NF-κB also significantly impacts autoimmunity and transplant rejection, making it an important therapeutic target. While the signaling molecules regulating this pathway are well-studied, the effect of changes in NF-κB signaling levels on T lymphocyte differentiation, fate, and function is not fully understood. Advances in computational biology and new NF-κB-inducible animal models are beginning to clarify these questions. In this review, we highlight recent findings related to T cells, focusing on how environmental cues affecting NF-κB signaling levels determine T cell fate and function.

Keywords