Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance

Patrick R. Smith; Sarah Loerch; Nikesh Kunder; Alexander D. Stanowick; Tzu-Fang Lou; Zachary T. Campbell

doi:10.1038/s41467-021-27160-4

Nature Communications (Nov 2021)

Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance

Patrick R. Smith,
Sarah Loerch,
Nikesh Kunder,
Alexander D. Stanowick,
Tzu-Fang Lou,
Zachary T. Campbell

Affiliations

Patrick R. Smith: The University of Texas at Dallas, Department of Biological Sciences
Sarah Loerch: Janelia Research Campus, Howard Hughes Medical Institute
Nikesh Kunder: The University of Texas at Dallas, Department of Biological Sciences
Alexander D. Stanowick: The University of Texas at Dallas, Department of Biological Sciences
Tzu-Fang Lou: The University of Texas at Dallas, Department of Biological Sciences
Zachary T. Campbell: The University of Texas at Dallas, Department of Biological Sciences

DOI: https://doi.org/10.1038/s41467-021-27160-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Processing bodies are phase separated compartments enriched in translationally repressed mRNAs. Here, Smith et al. show that, in sensory neurons, eukaryotic elongation factor 2 kinase (eEF2K) plays key roles in the regulation of processing body abundance and the formation of translationally inactive ribosomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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