P2.14 COMPARISON OF AGE-RELATED CENTRAL AORTIC BLOOD PRESSURE PARAMETERS USING TWO SPHYGMOCOR TECHNIQUES

Abstract

Background. Central aortic blood pressure (CBP) parameters are increasingly proved to be stronger predictors of cardiovascular outcomes than peripheral blood pressure parameters. Aortic stiffness, which increases with age, alters these parameters. The aim of this study was to compare the CBP parameters measured by two SphygmoCor techniques: tonometric (Classic) and cuff-based (XCEL) with respect to age. Methods: 186 individuals (mean age 68±45 years, range 21–93 years, 97 males) from general cardiac clinic patients were recruited. Tonometric and cuff-based assessment of central systolic blood pressure (cSBP), central diastolic blood pressure (cDBP), central pulse pressure (cPP) and augmentation index normalised to a heart rate of 75 beats/min (AIx75) was made in a randomized fashion after a period of seated acclimatization. Statistical analysis was performed by means of Analysis of Covariance (ANCOVA) with respect to device and age, with an interaction term between device and age to detect age dependent differences between devices. Results. All parameters changed significantly with age (p<0.001). There was no significant difference between all parameters estimated by the two techniques (Table). The interaction term of device and age was not significant for any parameter, indicating that the devices did not differ with respect to age. Conclusion. The new cuff-based SphygmoCor technique used for evaluation of CBP parameters in a clinical environment is a convenient and accurate proxy for the previous tonometric technique regardless of patient age. p Parameter Device Slope Intercept Device Age Age*device cSBP/age Classic 0.28±0.07 97±5 0.49 <0.001 0.58 (mmHg/yr) XCEL 0.23±0.06 101±4 cDBP/age Classic −0.16±0.04 82±3 0.66 <0.001 0.99 (mmHg/yr) XCEL −0.16±0.04 84±3 cPP/age Classic 0.45±0.06 14±4 0.55 <0.001 0.42 (mmHg/yr) XCEL 0.39±0.05 17±3 AIx75/age Classic 0.22±0.04 6±3 0.13 <0.001 0.38 (%/yr) XCEL 0.16±0.06 14±4 P2.15 Withdrawn by author