Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Apr 2009)
Association of Endometrial Hyperplasia with Some Risk Factors
Abstract
BACKGROUND AND OBJECTIVE: Endometrial cancer is one of the most common invasive gynecologic malignancies. Abnormal uterine bleeding (AUB) is the most common symptom in endometrial hyperplasia. Women with AUB are examined with dilation and curettage (D;C) to rule out any endometrial lesions including endometrial hyperplasia and carcinomas. This study was performed to determine the associated factors with endometrial hyperplasia.METHODS: This cross-sectional study was performed on 504 cases of D;C in Al Zahra teaching hospital, Rasht in 2005-2006. Cases were divided into two groups based on endometrial hyperplasia and absence of endometrial hyperplasia. Variables included: age of patients, menstrual pattern, high blood pressure, history of diabetes mellitus, contraceptive method used, nulliparity and infertility history were studied and compared.FINDINGS: There were 61 cases (12.1%) of endometrial hyperplasia including simple and complex (atypical and non–atypical). Independent factors associated with endometrial hyperplasia were diabetes mellitus (24.6% vs. 11.1%) (p<0.003), hypertension (27.9% vs. 16%) (p<0.02), and oligomenorrhea (32.8 vs. 13.5%) that had a statistically significant relationship with endometrial hyperplasia (p=0.0001). No significant relation was found between the age over 45 years, nulliparity, taking OCP and infertility history with endometrial hyperplasia.CONCLUSION: According to the results of this study, women with history of diabetes mellitus, high blood pressure, menstrual pattern and oligomenorrhea are high-risk group for endometrial hyperplasia and carcinoma. They should be examined by proper diagnostic procedures such as D;C.
