Armaghane Danesh Bimonthly Journal (Aug 2016)
The Effect of the Hydroalcoholic Extract of Dill ( Anethum graveolens( Seed on Lipid Profile in Diabetic Male Rats
Abstract
Background & aim: Nowadays, Diabetes is prevalent in different societies, and hyperlipidemia is one of the important outcomes and effective in the development of complications from this disease. Therefore, finding a medication to reduce hyperlipidemia without an adverse effects on blood sugar levels has always been investigated. Some studies have been reported the beneficial effects of the aerial parts of Anethum graveolens on lipid levels in the clinical and animal models. As there is no study on the effect of dill seed extract on blood lipid levels in diabetic rats; the aim of this study was to evaluate the effect of the dill seed extract on lipid profile in diabetic rats. Methods: In this experimental study, 24 rats with a weight range of 200 to 250 g were randomly divided into three groups of eight, including normal group, diabetic group (received normal saline) and diabetic group (received seed extract to 100 mg /kg). To induce diabetes, the rats were received streptozocin (50 mg /kg,) intraperitoneally. The dill seed extract was given for four weeks and then the blood samples were collected to measure LDL, HDL and triglyceride. The differences between the control and treatment groups were tested by one-way analyses of variance (ANOVA) followed by the Tukey post-hoc test. Results: Induction of diabetes significantly increased the serum concentration of LDL and triglycerides compared with the control group (p=0.001), but no effect was seen on HDL levels. Dill Oral administration of seed extract-dose (100 mg/kg) animal serum concentration of LDL significantly reduced in comparison with diabetic group (p=0.001). The triglyceride serum levels was significantly reduced compared to diabetic group after 4 weeks administration of dill seed extract (p<0.001), but no effect was observed on HDL in comparison to diabetic group (p=0.54). Conclusion: The results showed that the dill seed extract was able to reduce the serum levels of LDL and triglyceride in the diabetic rats. So it seems that this extract can reduce cardiovascular complications of diabetes through reducing the blood lipid profile.
