Effect of Supplementation with Hydroethanolic Extract of <i>Campomanesia xanthocarpa</i> (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet
Carla Maiara Lopes Cardozo,
Aline Carla Inada,
Claudia Andrea Lima Cardoso,
Wander Fernando de Oliveira Filiú,
Bernardo Barcelar de Farias,
Flávio Macedo Alves,
Mariana Bento Tatara,
Júlio Henrique Rosa Croda,
Rita de Cássia Avellaneda Guimarães,
Priscila Aiko Hiane,
Karine de Cássia Freitas
Affiliations
Carla Maiara Lopes Cardozo
Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79070-900, MS, Brazil
Aline Carla Inada
Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79070-900, MS, Brazil
Claudia Andrea Lima Cardoso
Departament of Chemistry, State University of Mato Grosso do Sul, Dourados 79804-970, MS, Brazil
Wander Fernando de Oliveira Filiú
Pharmaceutical Science, Food and Nutrition Faculty, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, MS, Brazil
Bernardo Barcelar de Farias
Diagnostic Medicine Laboratory-Scapulatempo, Campo Grande 79002-17, MS, Brazil
Flávio Macedo Alves
Institute of Biosciences, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, MS, Brazil
Mariana Bento Tatara
Health Science Research Laboratory, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil
Júlio Henrique Rosa Croda
Health Science Research Laboratory, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil
Rita de Cássia Avellaneda Guimarães
Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79070-900, MS, Brazil
Priscila Aiko Hiane
Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79070-900, MS, Brazil
Karine de Cássia Freitas
Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79070-900, MS, Brazil
There are still controversies regarding the correlation between the beneficial effects for health and the administration of isolated compounds or crude extracts in therapeutic applications. Campomanesia xanthocarpa, found in the Brazilian Cerrado, demonstrated beneficial effects in metabolic disorders associated with obesity. We investigated the effects of Campomanesia xanthocarpa hydroethanolic extract and two isolated substances from the extract (S1 and S2) in a diet-induced obesity (DIO) model. Male Swiss mice were divided into five groups: (1) American Institute of Nutrition (AIN-93M) diet, (2) high-fat diet (HF), (3) HF supplemented with C. xanthocarpa hydroethanolic leaf extract at 100 mg/kg (HFE), (4) HF supplemented with S1 at 1 mg/kg (HFS1) and (5) HF supplemented with S2 at 1 mg/kg (HFS2). The HFS1, HFS2 and HFE groups did not present decreasing body weight or visceral adiposity gain. No differences in glycemic and lipid parameters, or in the expression of protein content in two cytokines, interleukin-6 (IL-6) and anti-inflammatory (IL-10), were observed. Only the HFS1 group displayed decreased food intake. Even though substantial effects such as an improvement in obesity features or the metabolic and histological parameters promoted by S1, S2 and the extract were not observed, further investigations are necessary to evaluate the principal genes and protein expressions involved in regulating food behavior promoted by S1.
