Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction

Andrea S. Carlini; Roberto Gaetani; Rebecca L. Braden; Colin Luo; Karen L. Christman; Nathan C. Gianneschi

doi:10.1038/s41467-019-09587-y

Nature Communications (Apr 2019)

Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction

Andrea S. Carlini,
Roberto Gaetani,
Rebecca L. Braden,
Colin Luo,
Karen L. Christman,
Nathan C. Gianneschi

Affiliations

Andrea S. Carlini: Department of Chemistry & Biochemistry, University of California, San Diego
Roberto Gaetani: Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego
Rebecca L. Braden: Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego
Colin Luo: Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego
Karen L. Christman: Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego
Nathan C. Gianneschi: Department of Chemistry, Department of Materials Science & Engineering, Department of Biomedical Engineering, Simpson Querrey Institute for BioNanotechnology, International Institute for Nanotechnology, and Chemistry of Life Processes Institute, Northwestern University

DOI: https://doi.org/10.1038/s41467-019-09587-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Injectable hydrogels have gained significant interest; yet, due to high viscosity, many are unsuitable for catheter delivery. Here, the authors report on cyclic peptides with low viscosity for catheter delivery, which form self-assembled peptide hydrogels following enzymatic cleavage and demonstrated delivery in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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