S147: PIRTOBRUTINIB, A HIGHLY SELECTIVE, NON-COVALENT (REVERSIBLE) BTK INHIBITOR IN PREVIOUSLY TREATED CLL/SLL: UPDATED RESULTS FROM THE PHASE 1/2 BRUIN STUDY

• A. R. Mato,
• J. M. Pagel,
• C. C. Coombs,
• N. N. Shah,
• N. Lamanna,
• T. Munir,
• E. Lech-Maranda,
• T. A. Eyre,
• J. A. Woyach,
• W. G. Wierda,
• C. Y. Cheah,
• J. B. Cohen,
• L. E. Roeker,
• M. R. Patel,
• B. Fakhri,
• M. A. Barve,
• C. Tam,
• D. Lewis,
• J. N. Gerson,
• A. J. Alencar,
• C. Ujjani,
• I. Flinn,
• S. Sundaram,
• S. Ma,
• D. Jagadeesh,
• J. Rhodes,
• J. Taylor,
• O. Abdel-Wahab,
• P. Ghia,
• S. J. Schuster,
• D. Wang,
• B. Nair,
• E. Zhu,
• D. E. Tsai,
• M. S. Davids,
• J. R. Brown,
• W. Jurczak

Affiliations

A. R. Mato

1 Memorial Sloan Kettering Cancer Center, New York

J. M. Pagel

2 Loxo Oncology at Lilly, Stamford

C. C. Coombs

3 University of North Carolina at Chapel Hill, Chapel Hill

N. N. Shah

4 Medical College of Wisconsin, Milwaukee

N. Lamanna

5 Herbert Irving Comprehensive Cancer Center, Columbia University, New York, United States of America

T. Munir

6 Haematology, St. James’s University Hospital, Leeds, United Kingdom

E. Lech-Maranda

7 Institute of Hematology and Transfusion Medicine, Warsaw, Poland

T. A. Eyre

8 Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center, Oxford, United Kingdom

J. A. Woyach

9 The Ohio State University Comprehensive Cancer Center, Columbus

W. G. Wierda

10 MD Anderson Cancer Center, Houston, United States of America

C. Y. Cheah

11 Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia

J. B. Cohen

12 Winship Cancer Institute, Emory University, Atlanta

L. E. Roeker

1 Memorial Sloan Kettering Cancer Center, New York

M. R. Patel

13 Florida Cancer Specialists/Sarah Cannon Research Institute, Sarasota

B. Fakhri

14 University of California San Francisco, San Francisco

M. A. Barve

15 Mary Crowley Cancer Research, Dallas, United States of America

C. Tam

16 Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne, Melbourne, Australia

D. Lewis

17 Plymouth Hospitals NHS Trust - Derriford Hospital, Plymouth, United Kingdom

J. N. Gerson

18 Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia

A. J. Alencar

19 University of Miami Miller School of Medicine, Miami

C. Ujjani

20 Fred Hutchinson Cancer Research Center, Seattle

I. Flinn

21 Sarah Cannon Research Institute, Nashville

S. Sundaram

22 Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York

S. Ma

23 Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

D. Jagadeesh

24 Cleveland Clinic, Cleveland

J. Rhodes

25 Northwell Health Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, New Hyde Park, United States of America

J. Taylor

19 University of Miami Miller School of Medicine, Miami

O. Abdel-Wahab

1 Memorial Sloan Kettering Cancer Center, New York

P. Ghia

26 Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

S. J. Schuster

18 Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia

D. Wang

2 Loxo Oncology at Lilly, Stamford

B. Nair

2 Loxo Oncology at Lilly, Stamford

E. Zhu

2 Loxo Oncology at Lilly, Stamford

D. E. Tsai

2 Loxo Oncology at Lilly, Stamford

M. S. Davids

27 Dana-Farber Cancer Institute and Harvard Medical School, Boston, United States of America

J. R. Brown

27 Dana-Farber Cancer Institute and Harvard Medical School, Boston, United States of America

W. Jurczak

28 Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland