Nature Communications (Jul 2020)

Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation

  • Hemalvi Patani,
  • Michael D. Rushton,
  • Jonathan Higham,
  • Saul A. Teijeiro,
  • David Oxley,
  • Pedro Cutillas,
  • Duncan Sproul,
  • Gabriella Ficz

DOI
https://doi.org/10.1038/s41467-020-17269-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

Read online

Epigenetic reprogramming is a hallmark of cancer. Here the authors find that resetting primed human embryonic stem cells to naïve state results in the acquisition of a DNA methylation landscape that mirrors the cancer DNA methylome and provides evidence that the transition to naïve pluripotency and oncogenic transformation share common epigenetic trajectories.