Damage of cortical neurons after subarachnoid hemorrhage in rabbits

Abstract

Fresh autologous blood was injected into the cisterna magna to establish the model of spontaneous subarachnoid hemorrhage (SSAH) in the rabbit groups. The neuron apoptosis was observed by optical microscope and eletron microscope, and determination in apoptoic index. Observation by histopathology, neurons show tardive detriment, as cell body pyknosis, cytoplasm and nucleus hyperchromasis, karyoplasms uneven, fraction intranuclear caryotin agglomeration; even caryolysis, bioblast engorgement, crista resorbed. Contrast to blank groups, apoptotic index increased obviously in SAH groups, and statistical significant difference was seen among groups (all P < 0.05). Apoptosis plays an important role in delayed neuronal death after subarachnoid hemorrhage. DOI：10.3969/j.issn.1672⁃6731.2012.03.018

Keywords

• Subarachnoid hemorrhage
• Apoptosis
• Neurons
• Disease models, animal