Zhongguo linchuang yanjiu (Feb 2023)
Impacts of modified Gancao Ganjiang Decoction combined with moxibustion on dialysis adequacy and cardiovascular events in maintenance peritoneal dialysis patients with end-stage renal disease
Abstract
Objective To investigate the clinical effect of Gancao Ganjiang Decoction (GGD) combined with moxibustion on the patients with end-stage renal disease (ESRD) received maintenance peritoneal dialysis (PD). Methods Sixty-two ESRD patients received maintenance PD in the First Hospital of Hebei Medical University from June 2019 to June 2021 were selected and were randomly divided into control group and treatment group (n=31, each). The routine western medicine was given in control group, while the modified GGD combined with Yiqi Huiyuan moxibustion was added in treatment group based on the routine western medicine. After 4 weeks of treatment, the TCM syndrome scores, the dialysis adequacy ［serum creatinine (Scr), blood urea nitrogen (BUN), uric acid, estimated glomerular filtration rate (eGFR),residual renal function (RRF), residual renal urea clearance index (KT/V) and PD KT/V parameters］ and the cardiac injury biomarkers ［serum amino-terminal brain natriuretic peptide (NT-proBNP), creatine kinase-myocardial band (CK-MB), cardiac troponin Ⅰ (cTnⅠ) levels］ were observed and compared between two groups. Cardiovascular adverse events were observed during 6 months follow-up period. Results After treatment, TCM syndromes scores in treatment group were statistically lower than those in control group (P<0.05). Compared with those in control group, the levels of serum Scr, BUN and uric acid significantly decreased, and the levels of eGFR, RRF, PD KT/V and residual renal KT/V significantly increased in treatment group(P＜0.05）. The serum levels of NT-proBNP, CK-MB and cTnⅠ were lower in treatment group than those in control group (P<0.05). The incidence of cardiovascular adverse events in treatment group was significantly lower than that in control group during follow-up period (29.03% vs54.84%, P<0.05).Conclusion For ESRD patients receiving maintenance PD, modified GGD combined with moxibustion can enhance the dialysis adequacy, protect the residual renal function, improve the clinical symptoms and reduce the risk of cardiovascular events effectively.
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