Nature Communications (Nov 2016)

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

  • Line S. Reinert,
  • Katarína Lopušná,
  • Henriette Winther,
  • Chenglong Sun,
  • Martin K. Thomsen,
  • Ramya Nandakumar,
  • Trine H. Mogensen,
  • Morten Meyer,
  • Christian Vægter,
  • Jens R. Nyengaard,
  • Katherine A. Fitzgerald,
  • Søren R. Paludan

DOI
https://doi.org/10.1038/ncomms13348
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity in neurons and prime the TLR3-interferon pathway in astrocytes.