Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody

Tibor Füzik; Petra Formanová; Daniel Růžek; Kentaro Yoshii; Matthias Niedrig; Pavel Plevka

doi:10.1038/s41467-018-02882-0

Nature Communications (Jan 2018)

Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody

Tibor Füzik,
Petra Formanová,
Daniel Růžek,
Kentaro Yoshii,
Matthias Niedrig,
Pavel Plevka

Affiliations

Tibor Füzik: Structural Virology, Central European Institute of Technology, Masaryk University
Petra Formanová: Department of Virology, Veterinary Research Institute
Daniel Růžek: Department of Virology, Veterinary Research Institute
Kentaro Yoshii: Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University
Matthias Niedrig: Centre for Biological Threats and Special Pathogens, Robert Koch Institute
Pavel Plevka: Structural Virology, Central European Institute of Technology, Masaryk University

DOI: https://doi.org/10.1038/s41467-018-02882-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The tick-borne encephalitis virus (TBEV) causes thousands of cases of meningitis and encephalitis annually. Here, the authors describe a cryo-EM structure of the TBEV virion bound by Fab fragments of the neutralizing antibody 19/1786, revealing a mechanism whereby this antibody prevents virus membrane fusion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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