Cells (Dec 2021)

Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment

  • Ainhoa Hernández,
  • Marta Domènech,
  • Ana M. Muñoz-Mármol,
  • Cristina Carrato,
  • Carmen Balana

DOI
https://doi.org/10.3390/cells10123529
Journal volume & issue
Vol. 10, no. 12
p. 3529

Abstract

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Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.

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