Endoplasmic Reticulum Quality Control in Immune Cells

Yalan Jiang; Zehua Tao; Hua Chen; Sheng Xia

doi:10.3389/fcell.2021.740653

Frontiers in Cell and Developmental Biology (Sep 2021)

Endoplasmic Reticulum Quality Control in Immune Cells

Yalan Jiang,
Zehua Tao,
Hua Chen,
Sheng Xia

Affiliations

Yalan Jiang: Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China
Zehua Tao: Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China
Hua Chen: Department of Colorectal Surgery, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China
Sheng Xia: Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China

DOI: https://doi.org/10.3389/fcell.2021.740653
Journal volume & issue: Vol. 9

Abstract

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The endoplasmic reticulum quality control (ERQC) system, including endoplasmic reticulum-associated degradation (ERAD), the unfolded protein response (UPR), and autophagy, presides over cellular protein secretion and maintains proteostasis in mammalian cells. As part of the immune system, a variety of proteins are synthesized and assembled correctly for the development, activation, and differentiation of immune cells, such as dendritic cells (DCs), macrophages, myeloid-derived-suppressor cells (MDSCs), B lymphocytes, T lymphocytes, and natural killer (NK) cells. In this review, we emphasize the role of the ERQC in these immune cells, and also discuss how the imbalance of ER homeostasis affects the immune response, thereby suggesting new therapeutic targets for immunotherapy.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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Abstract

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